منابع مشابه
Prostaglandin Synthetase Inhibition
acterized in seven patients with Bartter's syndrome on constant metabolic regimens before, during, and after treatment with prostaglandin synthetase inhibitors. Patients with Bartter's syndrome had high values for plasma bradykinin, plasma renin activity (PRA), urinary kallikrein, urinary immunoreactive prostaglandin E excretion, and urinary aldosterone; urinary kinins were subnormal and plasma...
متن کاملInhibition of prostaglandin endoperoxide synthetase by thiol analogues of prostaglandin.
A variety of thiol compounds inhibited the enzymatic bis-oxygenation of 8,11,14-eicosatrienoic acid to prostaglandin G1, as examined with a purified preparation of prostaglandin endoperoxide synthetase (prostaglandin synthase; 8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase; EC 1.14.99.1) from bovine vesicular gland. The hydroperoxide cleavage of prostaglandin G1 producing prostag...
متن کاملTreatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors.
The diagnosis of Bartter's syndrome was made in a 9-month-old boy investigated for poor weight and height gain. Initial treatment with oral potassium supplements and later spironolactone had little or no effect on his growth, although plasma potassium rose to normal after spironolactone. At 33 months indomethacin therapy was started with dramatic results. His symptoms went and his height and we...
متن کاملThe structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi.
Sir: As reported in the previous paper,') thielavins A (1) and B (2) produced by Thielavia terricola SANK 10475 are potent inhibitors of prostaglandin (PG) synthetase. Thielavins A and B were shown to have 0-substituted salicylic acid as evidenced by UV absorption at 310"315nm in basic MeOH and 275 278 nm in acidic MeOH and by IR absorption at 1760, 1610 and 795 cm-1. Thielavins A and B possess...
متن کاملOxidative metabolism of diethylstilbestrol by prostaglandin synthetase.
The cooxidative metabolism of the transplacental carcinogen, diethylstilbestrol (DES), was examined using ram seminal vesicle microsomes. The major extractable metabolite was beta-dienestrol (Z,Z-DIES) and represented about 35% of the added DES in 3-min incubations supplemented with arachidonic acid. Its formation was dependent upon the presence of arachidonic acid, whereas reduced nicotinamide...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1981
ISSN: 0003-4967
DOI: 10.1136/ard.40.5.533-b